New Automated Cell Culture System for High-Throughput Top Clone Screening in CHO Cell Line Development

Find the right clones faster: The Cydem VT system combines four powerful technologies for earlier insights in finding the best clones for monoclonal antibody production.
Cydem VT

Learn How to Accelerate Top Clone Screening & Get Faster Insights

Offering the capabilities to screen more clones with the freedom to walk away from the instrument for up to three days during an experiment, the Cydem VT system leverages the advantages of automation and adds what’s been missing: earlier insights. It screens clones under conditions close to biomanufacturing production, while collecting vital data on cell growth and productivity all along the way.​

How does it do that? By combining a bioreactor, a liquid handler, a cell counter/viability anazyer, and a titer module into an automated stand-alone platform.

Screen 96 Clones at Once with a 3-Day Walk-Away Time

Cydem VT Key Features

Reduce errors by just letting it run on its own

Less manual work, fewer errors, reduced contamination risk: The fully automated cell culture workflow, including auto-normalization of cell density, allows you to leave the system unsupervised for 3 days on end.

Accelerate clone production

Maximize clone screening efficiency by obtaining detailed growth & production information on 96 clones at once, thus reducing the number of required screening steps before process development.

Optimize selection confidence

Daily measurements of cell count, viability and mAbs titer generate earlier insights into the growth and production of clones allowing for more informed decisions about top clone selection.

Screen under conditions close to biomanufacturing

Reduce the risk of selecting clones that do not scale—thanks to pH-controlled, fed-batch conditions with individual gassing regulation (CO2 & dissolved oxygen (DO)) in each parallel microbioreactor.

Simplify your experiments

With 96 x 5 mL microbioreactors, each measuring biomass, pH, DO, and mAbs titer, you simplify your experiments and generate trustworthy online data readouts. All data are centralized on one instrument and can be easily exported in .csv format

Streamline inefficient logistics

Sure, you could get a bioreactor, a liquid handler, a cell counter, and your titer assays from four different suppliers. Or you could streamline all of this: With one single point of contact for sales, service, and tech support for the entire Cydem VT system, consumables, and reagents.
Cydem VT

Video Develop Stable Cell Lines for mAb Therapeutics More Efficiently

Cydem VT video

Four Powerful Modules — One Stand-Alone Platform

Integrated bioreactor module

Cultivate 96 clones in 24-deep-well bioreactor plates in parallel
Online monitoring of pH, DO, and biomass
Unique gassing chip for well-individual gassing control
Maintain optimal pH and DO levels in your cultivations

Integrated cell count and viability module

Regular updates of cell count and viability throughout your entire experiment
Accurate and precise measurements with low sample volume (43 μL)
Utilizes our well-known Vi-CELL BLU Analyzer technology

Integrated titer module

Regular monoclonal antibody (mAbs) titer measurements
Small sample volume (10 µL)
Learn more about the productivity of your clones
Make informed decisions about your clone selection

Integrated liquid handler

Automate your top clone screening
Run more controlled fed-batch conditions and reduce the risk of selecting suboptimal clones
Automated inoculation and cell density normalization
Schedule builder for analysis, feeding strategy, and pH control

Download the Cydem VT Application Handbook

Want to learn more about Cydem VT’s application in cell line development? We have compiled four application notes into one PDF handbook.

Download it now and learn how to …

Set up your experiment on the Cydem VT system, including protocol considerations and data analysis options
Generate an antibody standard curve to accurately measure mAb titer in the cell line development process
Efficiently screen clones with increased process control and integrated cell health and titer measurements
Cultivate mammalian cells and obtain reliable and predictable cell health results for week-long fed-batch experiments

Clone screening of 96 clones over 14 days. Viable cell density and mAbs titer displayed over the course of the experiment. For a better overview, 10 clones with different growth and productivity performances were selected​.

Product in development. Performance characteristics have not been validated.

Product not for use in diagnostic or therapeutic procedures.