New Automated Cell Culture System for High-Throughput Top Clone Screening in CHO Cell Line Development
Find the right clones faster: The Cydem VT system combines four powerful technologies for earlier insights in finding the best clones for monoclonal antibody production.
Accelerate clone production
Optimize selection confidence
Reduce costly errors
Learn How to Accelerate Top Clone Screening & Get Faster Insights
Offering the capabilities to screen more clones with the freedom to walk away from the instrument for up to three days during an experiment, the Cydem VT system leverages the advantages of automation and adds what’s been missing: earlier insights. It screens clones under conditions close to biomanufacturing production, while collecting vital data on cell growth and productivity all along the way.
How does it do that? By combining a bioreactor, a liquid handler, a cell counter/viability anazyer, and a titer module into an automated stand-alone platform.
Screen 96 Clones at Once with a 3-Day Walk-Away Time
Reduce errors by just letting it run on its own
Less manual work, fewer errors, reduced contamination risk: The fully automated cell culture workflow, including auto-normalization of cell density, allows you to leave the system unsupervised for 3 days on end.
Accelerate clone production
Maximize clone screening efficiency by obtaining detailed growth & production information on 96 clones at once, thus reducing the number of required screening steps before process development.
Optimize selection confidence
Daily measurements of cell count, viability and mAbs titer generate earlier insights into the growth and production of clones allowing for more informed decisions about top clone selection.
Screen under conditions close to biomanufacturing
Reduce the risk of selecting clones that do not scale—thanks to pH-controlled, fed-batch conditions with individual gassing regulation (CO2 & dissolved oxygen (DO)) in each parallel microbioreactor.
Simplify your experiments
With 96 x 5 mL microbioreactors, each measuring biomass, pH, DO, and mAbs titer, you simplify your experiments and generate trustworthy online data readouts. All data are centralized on one instrument and can be easily exported in .csv format
Streamline inefficient logistics
Sure, you could get a bioreactor, a liquid handler, a cell counter, and your titer assays from four different suppliers. Or you could streamline all of this: With one single point of contact for sales, service, and tech support for the entire Cydem VT system, consumables, and reagents.
Four Powerful Modules — One Stand-Alone Platform
Integrated bioreactor module
Based on the BioLector XT Microbioreactor
Cultivate 96 clones in 24-deep-well bioreactor plates in parallel
Online monitoring of pH, DO, and biomass
Unique gassing chip for well-individual gassing control
Maintain optimal pH and DO levels in your cultivations
Integrated cell count and viability module
Based on the Vi-CELL BLU Cell Counter
Regular updates of cell count and viability throughout your entire experiment
Accurate and precise measurements with low sample volume (43 μL)
Utilizes our well-known Vi-CELL BLU Analyzer technology
Integrated titer module
Based on the Valita Titer IgG Quantification Assay
Regular monoclonal antibody (mAbs) titer measurements
Small sample volume (10 µL)
Learn more about the productivity of your clones
Make informed decisions about your clone selection
Integrated liquid handler
Based on the Biomek Liquid Handling Workstation
Automate your top clone screening
Run more controlled fed-batch conditions and reduce the risk of selecting suboptimal clones
Automated inoculation and cell density normalization
Schedule builder for analysis, feeding strategy, and pH control
Download the Cydem VT Application Handbook
Want to learn more about Cydem VT’s application in cell line development? We have compiled four application notes into one PDF handbook.
Download it now and learn how to …
Set up your experiment on the Cydem VT system, including protocol considerations and data analysis options
Generate an antibody standard curve to accurately measure mAb titer in the cell line development process
Efficiently screen clones with increased process control and integrated cell health and titer measurements
Cultivate mammalian cells and obtain reliable and predictable cell health results for week-long fed-batch experiments
Clone screening of 96 clones over 14 days. Viable cell density and mAbs titer displayed over the course of the experiment. For a better overview, 10 clones with different growth and productivity performances were selected.
Product not for use in diagnostic or therapeutic procedures.